纳络酮对缺血再灌注心肌儿茶酚胺释放的影响

Effects of naloxone on release of endogenous catecholamine in myocardium during ischemia and reperfusion in dog.

利用犬心肌缺血再灌注模型，观察了纳络酮对缺血再灌注心肌内源性儿茶酚胺释放和心肌ｃＡＭＰ、钙含量的影响。其结果表明：心肌缺血４０分钟，去甲肾上腺素大量释放，并伴有ｃＡＭＰ和钙含量增加；再灌注３０分钟后，这些指际变化更趋明显；纳络酮可以明显减少再灌注心肌去甲肾上腺素释放，同时降低心肌ｃＡＭＰ和钙含量，这可能是纳络团抗心肌缺血再灌注损伤的重要因素之一。

By using dog's model, the effects of naloxone on release of endogenous catecholamine and changes of cAMP and calcium in myocardium during ischemia and reperfusion were studied. The results were that myocardial endogenous catecholamine, especially NE, released significantly, accompanying the increased contents of cAMP and calcium in myocardium after 40 minutes of ischemia, the release of NE and alterations of cAMP and calcium in myocardium were more obvious in 30 minutes of reperfusion, and the naloxone limited the release of NE and prevented the in creasing of cAMP and calcium in reperfused myocardium . The findings demonstrated that naloxone hove a protective effect on myocardial ischemic-reperfusion injury.