普鲁卡因对维库溴铵阻滞过程、效应影响的时量研究

Quantitative study on effects of procaine upon neuromuscular blockade efficacy with vecuronium.

定量观测了普鲁卡因对静滴维库溴铵的阻滞过程、时效及两药对血清胆碱酯酶活性的影响。结果发现，（１）单纯静滴维库溴铵或配伍静滴普鲁卡因对血清胆碱酯酶活性影响轻微；（２）普鲁卡因能增强静滴维库溴铵的阻滞效应；（３）静滴普鲁卡因初始期增强维库溴铵的神经肌肉接头后膜阻滞作用，不影响其接头前膜的效应，对接头前膜的增加作用于２０～４０分钟出现，并保持在静滴普鲁卡因的全程中；（４）普鲁卡因延长维库溴铵阻滞后Ｔ１（四次成串刺激中第一个颤搐反应）恢复至２５％的时间，但不影响Ｔ；２５％自主或桔抗后恢复至Ｔ１、ＴＲ（四次成串刺激中第四与第一个颤搐反应之比）达７０％的时间。

The effects of procaine on neuromuscular blockade induced by continuous infusion of vecurium and both procaine and vecuronium on the activity of serum cholinesterase were quantitatively studied. The results were as follows: (l ) Activity of serum cholinesterase was affected mildly by vecuronium alone or both procaine and vecuronium infusion F (2 )Procaine potentiated the blockade efficacy of vecuronium; (3) In the initial stage of procaine infusion may potentiat vecuroniuminduced neuromuscular blockade of the postsynaptic membrane but not that of the presynaptic membrane. The potentiation action on the presynaptic membrane appeared within 20-40min and lasted in the whole course of procaine infusion; (4 )Procaine prolonged the recovery time of T, to 25 % after vecuronium-induced neuromuscular blockade,but it did not affect that of TI 25% to T1 TR > 70% spontaneously or antagonized by neostigmine.