前列腺癌、非典型增生的AgNOR数量变化的初步研究

Silver staining of nucleolar organizer regions in prostatic lesions

对４３例前列腺癌、３０例前列腺非典型增生及１９例良性前列腺增生症的石蜡包埋标本，应用核仁组成区染色技术系统地观察了核仁组成区（ＡｇＮＯＲ）的数量变化。结果显示：前列腺癌平均ＡｇＮＯＲ计数显著高于良性前列腺增生症者；前列腺非典型增生的ＡｇＮＯＲ计数介于良性增生症与癌组织之间，说明前列腺非典型增生具有潜在的恶性病变。前列腺癌平均ＡｇＮＯＲｓ计数与组织学分级关系密切，随肿瘤组织的分级增高而增高，不同的组织分级之间其平均ＡｇＮＯＲ计数有显著的差异，提示ＡｇＮＯＲ颗粒与前列腺癌的分化程度有关。

Variation in the number of silver-stained nucleolar organizer region-assiociated proteins (AgNORs) were studied in paraffin sections of 43 prostatic adenocarcinoma , 30 dysplasia and 19 benign hyperplasia. There was a significant difference between the mean AgNORs counts in the normal cells, dysplasia cells and tumor cells. The mean AgNORs counts significantly increased with increasing grade of tumor. AgNORs counting might contribute to the conventional diagnostic indicater of the prostatic lesions.