抗胸腺淋巴细胞球蛋白治疗移植肾难治性急性排斥反应

Lymphogloline in the treament of refractory acute rejection after renal transplantation

报告我院１９９２年１０月～１９９３年８月在应用环孢素Ａ（ＣｓＡ）治疗的尸体肾移植患者中２０例发生难治性急性排斥反应（ＡＲ），经应用抗胸腺淋巴细胞球蛋白（ＡＴＧ），治疗１９例完全逆转（９５％），１例改用ＯＫＴ＿３逆转。应用证实，ＡＴＧ安全有效、特异性强、反应灵敏、副作用小。就发生难治性ＡＲ的原因、诊断与鉴别诊断，ＡＴＧ与ＣｓＡ的关系，以及ＡＴＧ治疗移植肾难治性难治性ＡＲ的价值进行讨论。

Among the patients who were treated with cyclosporin A(CsA)after renal transplantation from Oct.1992 through Aug.1993, 20 cases devoloped refractory acute rejection(RAR).In 19 the rejection was reversed completely with Lymphogoling(ATG) while in the other the rejection was reversed with OKT3. The results suggest that ATG is safe, effective,highly specific and with least side effect.The pathogenesis,diagonsis and differential diagnosis of RAR, the relatinoship between ATG and CsA,and the value of ATG in the treatment of RAR after renal transplantation were discussed.