前列腺特异性抗原密度的测定在诊断前列腺癌中的价值

Diagnostic value of prostate specific antigen density in prostate cancer

对１０例非转移性前列腺癌和２０例前列腺增生的前列腺特异性抗原密度（ＰＳＡＤ）进行研究。前列腺癌平均ＰＳＡＤ值为０．７１１，而前列腺增生为０．０７５；两者有极显著性差异（Ｐ＜０．００１）。９例ＰＳＡＤ＞０．２者，８例为前列腺癌。１６例ＰＳＡＤ＜０．１者，无１例前列腺癌。８例前列腺癌患者中有３例前列腺特异性抗原（ＰＳＡ）＜１０ｎｇ／ｍｌ，１例＜２．８ｎｇ／ｍｌ。１６例前列腺增生患者中７例ＰＳＡ＞２．８ｎｇ／ｍｌ，３例＞１０ｎｇ／ｍｌ。表明血清ＰＳＡ轻中度增高或正常时，ＰＳＡＤ可作为前列腺癌早期筛选诊断的有效指标之一。

Prostate specific antigen desity (PSAD)was studied in 10 cases of non-metastatic prostate cancer and 200cases of BPH.The mean PSAD values for prostate cancer and BPH were 0. 711 and 0. 075 respectively(P<0. 001). 8 out of 9 patients with PSAD greater than 0.2 had prostate cancer, in which 3 had a PSA less than 10ng/ml and 1 below 2. 8 ng/ml. In contrast. none of the 16 patients with PSAD less than 0. 1 had prostate cancer.Furthermore,7 out of 16 BPH patients were found to have a PSA greater than 2. 8 ng/ml and another 3 greater than 10ng/ml.these results showed that PSAD might be an effective indicator in screening early prostate cancer when the serum PSA has been moderately elevated or normal.