人肾细胞癌组织中氧自由基及其抗氧化酶活性的初步研究

A preliminary studies on the oxygen free radicals and antioxidant enzyme in human renal cell carcinoma

通过对２１例肾细胞癌组织及正常肾组织中脂质过氧化物（ＬＰＯ）含量、超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活力测定，发现肾细胞癌组织中ＬＰＯ含量高于正常肾组织（Ｐ＜０．０５）；肾细胞癌组织中ＳＯＤ和ＧＳＨ－ＰＸ活力低于正常肾组织（Ｐ＜０．０５，Ｐ＜０．０１），并且ＬＰＯ和ＧＳＨ－ＰＸ变化与肾细胞癌分期有关。结果提示，氧自由基及其抗氧化酶可能参与肾细胞癌的发生和发展。

Lipid peroxide (LPO), superoxide dismutase (SOD) and glutathione-peroxidase (GSH-PX) activities were determined in renal cell carcinoma (RCC) and tumor-uninvolved renal tissues in 21 patients with renalcancer. The results showed that LPO in RCC was increased than in nomal renal tissues (P<0.05). While SOD and GSH-PX were significantly reduced (P<0.05,P<0.01). The stage of tumors had apparent effect on LPO value and GSH-PX activity. It is suggested that oxygen free radicals and antioxidant enzyme might play an important role in the initiation and promotion of renal cell carcinogenesis.