前列腺癌及前列腺增生组织EGF、EGFr表达的差异及意义

Expression of EGF, EGFr and their significance in benign prostatic hyperplasia and prostatic carcinoma

对前列腺增生症及前列腺癌中ＥＧＦ、ＥＧＦｒ表达进行了观察。７５％ＢＰＨ表达ＥＧＦ，５８％ＢＰＨ有ＥＧＦｒ阳性染色。２７例前列腺癌中１３例（４８％）ＥＧＦ阳性，仅４例（１５％）表达ＥＧＦｒ。ＥＧＦｒ在前列腺癌中低水平表达可能与原癌基因Ｃ－ｅｒｂＢ－１表达调控有关。本研究未能发现ＥＧＦｒ表达与肿瘤组织学类型及预后的关系。因此认为对ＥＧＦｒ在肿瘤组织中表达的临床意义的解释应慎重。

The distribution and significance of epidermal growth factor (EGF) and its receptor (EGFr) in benign prostatic hyperplasia and prostatic carcinoma were evaluated.75% of BPH expressed EGF and 58% EGFr.About 48% (13/27) prostatic carcinoma showed positive staining for EGF while only 4 (15%) expressed EGFr. The lower level of EGFr expression in prostaticcarcinoma might relate to the regulation of procogen of C-erbB-1. No correlation between EGFr expression and the histological type of tumor neither the prognosis was observed. The evaluation of the significance of EGFr expression in clinical practice should therefore be prudent.