不能手术的妇科恶性肿瘤的介入治疗

Interventional treatment of unrese ctable malignant tumor in gynecology

目的探讨介入治疗对不能手术的妇科恶性肿瘤的疗效。方法27例患者,其中卵巢癌14例,子宫内膜癌5例,宫颈癌8例,经妇检、B超、CT确诊为晚期且失去手术机会。采用Selding氏法,经单侧股动脉插管,行DSA后,将导管超选至双侧髂内动脉供血动脉近端,注入以铂类为主的3种化疗药,并栓塞肿瘤或/和转移灶供血动脉。结果介入治疗1至4次后,所有病人临床症状明显改善,瘤体有不同程度缩小。其中5例于首次治疗后2周,行肿瘤根治术,术后3个月继续介入治疗,随访结果表明,患者生存质量提高,中位生存期19个月。化疗的副作用明显低于全身静脉给药。结论介入治疗为不能手术的妇科恶性肿瘤患者提供了一种安全、有效的治疗方法。

Objective To explore the efficacy of intervent ional treatment for unresectable ma lignant tumors in gynecology.Methods Twenty -seven patients with terminal cancer including 14oophorogenous.5endometrial,and 8cervical cancer proven by gynecological examination,CT and ultrasonograph y underwent the interventional treatment.The study was performed using Selding' s technique i.e.catheter was introduced into th e proximal and of bilateral internal iliac arteries through unilateral f emoral artery and then three kinds of chemothe rapeutic agents with predominant platinum were injected in ord er to embolize blood supply arteries of tumors and metas-tases.Results Following interventional treatmen t for once to four times,the clinical symptoms were improved significant ly and the size of tumors were more or less diminished e ven disappeared in all patients.Of t hem,5patient received radical operation at third week after first chemotherapy and then continuously received interventional trealmen f or three months.The follow -up survey showed that the living quality in all patients was improved,their m ean survival terms were 19months,an d adverse reactions from chemothera py were less than that from venous administation.Conclusion Interventional treat is a safe and ef fectual method for unresectable malignant tumors in gynecology.[