选择性肝动脉化疗药物灌注及栓塞治疗肝转移癌

Selective hepatic arterial infusio n chemotherapy and embolization in t he treatment of liver metastases

目的探讨选择性肝动脉化疗药物灌注及栓塞治疗肝转移癌的价值。材料与方法对122例失去手术机会的肝转移癌患者,采用经股动脉穿刺,选择性肝动脉插管灌注化疗药物ADM,MMC,CDDP,5-FU,并用ADM及碘化油乳化后检塞肝动脉。结果近期疗效以CT检查结果作为评价标准,总有效率为54%66/122,平均生存期22.2个月。0.5、1、2、3年生存率分别是98.3%、80.4%、40.9%、10.6%。结论经肝动脉化疗药物灌注及栓塞治疗是失去手术机会的肝转移癌患者的一种安全、有效的姑息性治疗方法,其不仅能提高疗效,而且能改善患者的生活质量。

Objective To evaluate the efficacy of selectiv e hepatic arterial infusion chemoth erapy and embolization in the treatm ent of unresectable liver metastases.Methods Percutaneous selective hepatic arterial infusion chemotherapy(Abriamycin,mitomycin,Cisplatin,5-fluorouracil)and embolization(mixture of iodic oil and ADM)was performed in 122patients with unresectable liver metastases.Results An overall response rate(CR +PR)of all cases after the teatment was 54%.The mean survival period of 122patients was 22.2months.The0.5-,1-,2-,and 3-year survival rat e was 98.7%,80.8%,40.9%,and 10.6%,respectively.Conclusion The hepatic artery in-fusion chemotherapy and embolization is a safe and effective palliative treatment for patients with unresec table liver metastases.[