胰腺癌中p16蛋白阳性表达的价值

The Value of P16 Positive Expression in Pancreatic Cancer

目的 观察p16蛋白在胰腺癌中的表达 ,探讨其与胰腺癌临床病理学特征及预后的关系。方法 采用免疫组织化学S -P法检测p16蛋白在 4 0例胰腺癌、12例胰腺浆液性腺瘤、16例胰腺炎中的表达情况。结果 p16蛋白在胰腺癌中表达率明显低于胰腺炎及胰腺浆液性腺瘤 ,且p16蛋白在胰腺癌分期及导管腺癌高、中、低分化组间表达有显著差异。结论 p16蛋白的表达与胰腺癌的分级和分期的关系密切 ,p16基因可作为判定瘤细胞恶性程度及预后的客观指标。

Objective To study the expression of p16 in pancreatic cancer and the relationships among the expression,the clinical patheological characteristics and the prognosis.Methods The expressions of p16 in 40 cases of pancreatic cancer, 12 cases of pancreatic serous adenoma and 16 cases of pancreatitis were detected through the immunohisochemistry S-P method. Results The expressing rate of p16 in the pancreatic cancer was much lower than those in pancreatic serous adenoma and pancreatitis, there was obvious differences of expression in the level of pancreatic cancer and ductal adenocarcinoma differentiation of high, medial and low degrees. Conclusion The expression of p16 is closely related to the level and classification of pancreatic cancer, the gene of p16 can be the index of judging the melignant degree of oncocyte and the prognosis.