甲酰四氢叶酸、氟脲嘧啶、顺铂方案治疗转移性乳腺癌疗效观察

Follic acid 5-Fluorouracil Cisplatin Regimen in the Treatment of Metastatic Breast Cancer

目的 观察甲酰四氢叶酸、氟脲嘧啶、顺铂组成的方案作为一线方案治疗初治的复发、转移乳腺癌的近期疗效、毒副作用。方法 选择符合入组条件的病人 ,用甲酰四氢叶酸、氟脲嘧啶、顺铂组成联合化疗方案LFD ,计划每个病人至少用 2周期 ,最多用 6周期 ,观察LFP方案治疗转移性乳腺癌的近期疗效、化疗的毒副作用。结果 LFD方案治疗复发、转移乳腺癌的有效率为 5 5 .3% ,1、2、3年生存率为 6 7.3%、4 2 .1%、2 8.3% ;影响疗效的因素为月经状态、转移部位、转移器官数目、是否接受过含蒽环类药物的辅助化疗、术后无复发生存间期 ;主要毒副作用为恶心呕吐、口腔炎、腹泻等 ,心脏毒性轻微 ,Ⅲ、Ⅳ度毒性发生率低 ,病人耐受性好 ,无治疗相关死亡。结论 LFP方案是治疗复发、转移乳腺癌的有效方案 ,毒副作用多轻微 ,特别是心脏毒性小 ,耐受性好 ,可做为一线方案。

Objective To observe the short term effects and toxic side effects of LFP regimen as the first-line therapy in the treatment of the recurrent and metastatic breast cancer after initial chemotherapy. Methods Choose the patients confirmed to the enrollment standard, each patient was given 2 courses at least or 6 courses at most of chemotherapy with Folinic acid 200mg/m 2 within 2 hours,followed by continous intravenous infusion of 5-Fluorouracil 750mg/m 2/d for l20 hours, cisplatin 20mg/m 2 on (LFP regimen). The treatment was recycled every 3 weeks and the short term effects and toxic side effects were recorded. Resutls The response rate of chemotherapy with LFP regimen in the treatment of metastatic breast cancer was 55.3%. The l-; 2-;,and 3-year survival rate was 67.3%, 42.l% and 28.3% respectively. The factors impacting the treatment resluts were menstrual status, metastatic site, numbers of metastatic organs, with or without adjuvantive chemotherapy including anthracycline, postoperative survival duration without recurrance.The toxic side effects were mainly nausea, vomiting, oral mucositis and diarrhea etc. Cadiotoxicity was mild and toxicity of grade III-IV were hardly observed. The patients were well toleralbe and also no death related to the chemotheapy was occurred. Conclusion LFP regimen as the first-line therapy with mild toxicity and particu1ar low cadiotoxicity is worth using in the treatment of recurrent and metastatic breast cancer