支气管哮喘患者外周白细胞糖皮质激素的受体变化

THE CHANGE OF GLUCOCORTICOID RECEPTORS IN PERIPHERAL LEUKOCYTES INASTHMATIC SUBJECTS

用放射配基结合分析法测定了外源性及内源性哮喘患者外周白细胞糖皮质激素受体（ＧＣＲ）水平，同时测定其血浆皮质醇水平。结果发现哮喘患者ＧＣＲ水平较正常对照组明显降低（Ｐ＜０．０１），其降低程度与疾病初发年龄、病程密切相关，而哮喘患者血浆皮质醇水平与正常对照组无显著差异性。提示哮喘患者肾上腺皮质功能尚未受到明显损害，但其ＧＣＲ功能存在异常。关于哮喘患者ＧＣＲ功能异常原因，我们推测与哮喘患者遗传倾向有关，同时与环境因素反复刺激、疾病反复发作有关。

he number of glucocorticoid receptors(GCR)in peripheral leukocytes was detennined byradioligand一bi nding assay in extrinsic and intrinsic a sthmatics.Their corresponding plasma corti sollevels were assessed. The results showed tha the averagen umber of GCR in asthma tics wassignificantly lower than that in heaIthy subjects(P<0.01),and there was a linear correlation betweenthe number of GCR and the course of asthma。Besides,there was also alinear correlation between thenumber of GCR and the age of the initial attack of asthma. No difference in plasma cortisol level wasfound between asthmatics and heaIthy subjects.These findings suggest that there is no primary and gen-eral impairment of glucocorticoid metabolism in the asthmatics,but the number of GCR in the asthmat-ics is lower than that in heaIthy controls.The decrease ofthe number of GCR in asthmatics, we thinK isrelated to heredity and repeated attacks of asthma。