丁咯地尔治疗脑梗死的临床及血流动力学研究

Clinical and Blood Dynamic Study of Buflomedil vs Dancen in Treating Cerebral Infarction

目的 研究丁咯地尔治疗脑梗死的临床疗效并观察其对血流动力学的影响。方法 10 0例脑梗死病人 ,随机分为治疗组和对照组 ,治疗组采用丁咯地尔注射液 2 5 0ml (含丁咯地尔 10 0mg) ,静脉滴注 ,一日一次 ,14天为一个疗程 ;对照组采用丹参注射液 2 5 0ml,静滴 ,一日一次 ,14天为一个疗程 ,观察临床疗效及血流动力学改变。结果 治疗组总有效率 92 % ,显效率 62 %。对照组总有效率 64% ,显效率 30 % (P <0 .0 5 )。丁咯地尔对脑循环动力学有显著改善 (P <0 .0 1) ,且不良反应较少。

Objective To compare buflomedil (Buf) vs Dancen in treating cerebral infarction.Methods Fifty patients with cerebral infarction were treated with Buflomedil Hydrochloride injection 250ml (100mg),iv drip,qd for 14d.other 50 patients were treated with Dancen injection 250mL,iv drip,qd for 14d. Results Buflomedil group yielded a total response rate 92% and regression 62%,which were higher than those of Dancen group 64 %and 30%(P<0.05) respectively.Buflomedil also improved brain circulation dynamics (P<0.01),and adverse reaction was mild.Conclusion Buflomedil is better than Dancen in treating cerebral infarction.