巯甲丙脯酸用于流行性出血热治疗临床观察

Clinical Observation of Captopril in the Treatment of Epidemic Hemorrhagic Fever

目的 观察巯甲丙脯酸用于流行性出血热治疗的临床效果。方法 病人随机分为A、B、C 3组 ,A组在进入少尿期口服巯甲丙脯酸 2 5mg ,日 3次 ;B组在少尿期并发高血压时开始服用 ,剂量方法同A组。C组在少尿期并发高血压时口服复方降压片 1～ 2片 ,每日 3次。其他治疗相同。结果 A组无 1例发生高血压 ;B组用药后 4～ 6小时血压开始下降 ,72小时后血压稳定且正常。C组血压偏高。A、B组肾功能恢复快 ,并发症少 ,病程短。结论 巯甲丙脯酸用于治疗流行性出血热可减少或防止急性肾功能衰竭 。

Objective To observe the clinical effect of captepril on the epidemic hemorrhagic fever. Methods The patients were randomly divided into 3 groups:group A,group B and group C.Group A was given orally captopril 25mg 3 times daily before oliguric stage; group B was administrated the same dose of captopril as group A in obliguric stage complicated with hypertension; group C was given orally 1 to 2 compound hypotensive tablets 3 times daily. The other treatments were the same as the 3 groups Results There was no hypertension in group A, in group B, the blood pressure began to decrease 4 to 6h after treatmeat, 72h later it returned and maintained the normal level. In group C, the blood pressure was higher than normal. In group A and group B, the renal function recovered more quickly, complications were fewer and the duration of illness was shorter than those in group C. Conclusion Captopril can decrease or prevent acute renal failure, decrease the complication in the treatment of epidemic hemorrhagic fever.