三种方法预防产后出血的临床观察

Clinical Study on Reduction of Postpartum Hemorrhage by Three Methods

目的 观察米索前列醇用于预防足月分娩产后出血的效果。方法 选择 50 5例足月分娩者 ,随机分为三组 :米索前列醇组 175例 ,胎儿肩娩出后即口服米索前列醇 4 0 0 μg ;催产素组 16 0例 ,胎儿肩娩出后即肌注催产素 2 0IU ;米索前列醇加催产素组 170例 ,胎儿肩娩出后即口服米索前列醇 4 0 0 μg ,同时肌注催产素 2 0IU。结果 产后 2h内平均出血量 ,米索前列醇组 :174 .2 7± 2 9.76ml ;催产素组 :2 96 .17± 32 .54ml;米索前列醇加催产素组 :170 .4 3± 33.16ml。米索前列醇组与催产素组比较 ,差异极具显著性 (P <0 .0 1)。米索前列醇组与米索前列醇加催产素组比较 ,差异无显著性 (P >0 .0 5)。结论 米索前列醇与催产素比较 ,前者有更强的子宫收缩作用 ,可降低产后出血率 ,比单用催产素疗效好。

Objective To observe the effects of Misoprostol on prevention of postpartum hemorrhage in term labor. Methods 505 term labors were randomly divided into three groups: the Misoprostol group, 175, 400mg Misoprostol was given orally immediately after delivery of the baby shoulders;the Oxytocin group,160, 20 IU Oxytocin was injected into muscle immediately after delivery of the baby shoulders; the Misoprostol and Oxytocin group,170, 400ug Misoprostol was given orally and 20 IU oxytocin was injected into muscle immediately after delivery of the baby shoulders. Results The mean amount of bleeding witnin 2 hours after delivery in the Misoprostol group was 174.27±29.76 ml, the Oxytocin group was 296.17±32.54ml,the Misoprostol and Oxytocian group was 170.43±33.16ml . The difference was significant (P <0.01) between the Misopostol group and the Oxytocin group.There was no difference between the Misoprostol group and the Misoprostol plus Oxytocin group(P > 0.05).Conclusion Misoprostol can reduce the rate of postpartum hemorrhage,and it is better than the single use of oxytocin.