某地区慢性肝病与乙型和丙型肝炎病毒感染关系分析

Relationship Analysis of Chronic Liver Disease and Hepatitis B and Heptitis C Virus Infection

目的 探讨慢性肝病与乙型丙型肝炎病毒感染的关系。方法 EIA法检测HBV感染指标 (两对半系统 )及抗HCV ,PCR法检测HBVDNA ,反转PCR法检测HCVRNA。结果 32 8例慢性肝病患者中 ,HBV感染率明显高于HCV感染率 (P <0 .0 5) ,肝癌患者中HBV、HCV重叠感染率明显高于慢性肝炎组 (P <0 .0 5)。结论 该地区慢性肝病仍以HBV感染为主 ;HBV、HCV重叠感染对肝癌的发生似有相加作用。

Objective To study the relation between chronic liver disease and HBV and HCV infection.Methods Serological markers of HBV and HCV infection were tested by EIA;HBVDNA by PCR;HCVRNA by RT-PCR.Results The infection rate of HBV was significantly higher than that of HCV, (P<0.05);superinfection rate of HBV and HCV of Hepatocellular Carcinoma was significantly higer than that of chronic hepatitis(P<0.05). Conclusion HBV is still the main pathogenic factor of chronic liver disease in the area,superinfection of HBV,HCV may accelerate the progress of liver cancer.