放免分析测定血清SF、β_2-MG和CEA对卵巢恶性肿瘤诊断的意义

Significance of RIA Measurement of SF,β_2-MG,CEA to Ovarian Neoplasm Tumours Diagnosis

目的 探讨血清铁蛋白、β2 -微球蛋白和癌胚抗原在诊断卵巢恶性肿瘤中的价值。方法 用放射免疫法测定卵巢肿瘤患者 6 3例和健康女性 30例的血清铁蛋白、β2 微球蛋白和癌胚抗原的水平。所获数据经 χ2 检验。结果 卵巢恶性肿瘤患者的血清铁蛋白、β2 微球蛋白和癌胚抗原均高于良性肿瘤组和正常对照组 ,差异显著 (P <0 .0 1) ,良性组和对照组比较 ,差异无显著性 (P >0 .0 5) ;Ⅲ～Ⅳ期者铁蛋白高于Ⅰ～Ⅱ期者 ;铁蛋白和β2 微球蛋白联合检测优于单项检测 ,Ⅰ～Ⅱ期患者的诊断敏感性达 6 3.6 4 %。结论 SF、β2 -MG和CEA可作为肿瘤标记物 ,用于肿瘤诊断和良恶性鉴别诊断及病情监测。作为恶性肿瘤的筛选指标 ,可减少误诊。

Objective To study the value of ferritin(SF),Beta2-microglobulin(β 2-MG) and carcino embryonic antigen (CEA) for the diagnosis of malignant ovarian neoplasm. Methods Sixty three patients of ovarian neoplasm and 30 healthy subjects were assayed for SF,β 2-MG and CEA with radioimmunoassay.Results The average content of tumor markers in ovarian cancer was higher than that in the bengin and healthy subjects.There was notable difference (P<0.01). The healthy group and the control group had no difference (P>0.05).The level of SF was higher in stage Ⅲ and Ⅳ patients of ovarian cancer than that in stageⅠ and Ⅱ. Combined SF and β 2-MG were superior to using one marker for the diagnosis of ovarian cancer. The diagnostic sensitity was 63.64% in stage Ⅰand Ⅱ patients of ovarian cancer. Conclusion SF-B2-MG and CEA can be used as tumour marker to diagnose tumour and mornitor the disease.As the selected index of malignant tumour,it can reduce the misdiagnosis.