干扰素联合无环鸟苷治疗慢性乙型肝炎30例疗效观察

Effect Observation of Interferon Combined with Aciclovir Treating 30 Cases of Chronic Viral Hepatitis B

目的 观察干扰素联合无环鸟苷治疗慢性乙型肝炎的临床疗效。方法 选取 60例慢性乙肝患者 ,随机分为A、B组 ,A组、B组均用一般保肝药物 ,A组加用α - 1b干扰素 30 0万u肌注 ,每周 3次 ,无环鸟苷口服 ,每次 0 .4 g ,每日 3次 ,疗程 3个月～ 6个月。 结果 干扰素联合无环鸟苷对症状、体征改善及肝功能恢复及HBeAg、HBsAg转阴较对照组疗效显著 (P <0 .0 5) ,而且副作用少。

Objective To observe the clinical effect of interferon combined with Aciclovir in the treatment of chronic viral hepatitis B.Methods Choose 60 patients with chronic hepatitis B and divide randomly into group A and group B, both of which were treated with common liver-curing medicines. Group A was treated additionally with α-1b interferon 3,000,000u by mulse injection, three times per week,taking Aciclovir 0.4g per time, three times daily lasting 3～6 months. Results Interferon with Aciclovir had a more obvious effect than group B in the treatment of chronic hepatitis B in elimating symptoms and clinical signs and recovering liver function with HBeAg,HBsAg,turning to negative (P<0.05) and this method had less side effects.Conclusion Interferon combined with Aciclovir is an effective method in the treatment of chronic hepatitis B.