国人A型行为与冠心病关系的Meta-analysis──9个病例对照研究的合并分析

Meta-analysis of Type-A Behaviour and Coronary Heart Disease in China ── Combined Analysis of Nine Case-control Studies

目的 探讨国人A型行为与冠心病的关系 ,更进一步明确冠心病病因。方法 应用Meta -analy sis方法对国内 9个有关A型行为与冠心病关系的病例对照研究进行综合定量分析。累积病例为 1139人 ,对照为 967人。采用Fleiss模型和DersimonianandNanLaird(D -L)模型方法处理数据。结果 表明A型行为与冠心病有关 ,采用Fleiss模型计算综合OR为 2 .32 ( 1.93～ 2 .79) ,D -L模型计算合并OR为 2 .32 ( 1.80～ 2 .99)。还对影响本研究的可能偏倚和混杂因素进行了讨论。结论 A型行为特征增加了易患冠心病的危险 ,提示我们应从社会 -生物

Objective To study type-A Behaviour and Coronary Heart Disease in China,in order to define the pathogeny of Coronary Heart Disease.Methods 9 case-control studies on the relations between type-A Behaviour and CHD in China were analysed by means of Meta-analysis.The cumulative case and controls were 1139 and 967 respectively.Fleiss's model and Dersimonian and Nan Laird's model were applied to process data.Results The results showed statistically significant correlation between type-A Behaviour and CHD.The pooled OR was 2.32 (1.93～2.79) in Fleiss's model and 2.32 (1.80～2.99) in D-L's model.In addition,the bias and comfounding that could affect the result of the study were also discussed.Conclusion Type-A Behavior increases the danger of being sick with CHD,which suggests we ought to make a counter plan basing bio-psy-soc-medical model to prevent and treat CHD.