尼莫通治疗脑弥漫性轴索损伤的临床研究

Clinical Research on Nimotop in the Treatment of Brain Diffuse Axonal Injury

目的 探讨尼莫通在脑弥漫性轴索损伤中的治疗作用。方法 将我院同期住院的脑弥漫性轴索损伤的病人 52例 ,随机分为尼莫通治疗组 2 7例 ,对照组 2 5例 ,于治疗前后行GCS评分 ,并评价临床疗效。结果 治疗组GCS得到不同程度的提高 ,阻止了病情恶化 ,死亡率 18.5% ,与对照组相比有明显差异 (P <0 .0 5) ,且未发现明显副作用。结论 尼莫通在脑弥漫性轴索损伤的治疗中能降低死亡率 ,减轻意识障碍 ,提高生存质量 ,副作用小。

Objective To explore the effect of Nimotop in the treatmeant of the brain diffuse axonal injury. Methods 52 patients with brain diffuse axonal injury who admitted to our hospital at the same period were divided randomly into the treatment group (27 cases) treated with Nimotop and the control group (25 cases) treated with routine therapy.Glasgow Coma +Scale (GCS) and clinical effect were examined before and after management respectively.Results GCS was improved in various degrees and deterioration was prevented in the treatment group. The death rate was 18.5%.There was significiant difference compared with the control group (P<0.05) and no obvious side effects were found.Conclusion Nimotop treatment can diminish death rate, decrease the degree of the coma and improve quality of subsistence for the brain diffuse axonal injury with less side effects.