人膀胱肿瘤中癌基因C－erbB－1／EGFR的分布及意义

Distribution and significance of oncogene C-erbB-l/EGFR on human bladder carcinoma

应用原位分子杂交和免疫组化对５８例膀胱肿瘤中癌基因Ｃ－ｅｒｂＢ－１／ＥＧＦＲ进行了研究。结果显示Ｃ－ｅｒｂＢ－１／ＥＧＦＲ在ｍＲＮＡ转录丰度和蛋白质表达上的阳性率为３３．３％和３４．５％。其阳性率在肿瘤病理分级、临床分期及预后等方面差异有显著性（Ｐ＜０．０５）。提示Ｃ－ｅｒｂＢ－１／ＥＧＦＲ参与了膀胱肿瘤的恶性转化过程，是判定膀胱肿瘤恶性程度及预后的一项重要指标。

cases of bladder carcinoma were studied by in situ hybridization(ISH)and immunohistochemical technique(IHC). The results showed that the positive rate of mRNA and protein of C-erbB-l/EGFR were 33.3% and 34.5%respectively, their positive rates being significantly different with different pathological grading and clinical staging of the carcinoma(P<0. 05 ). It suggests that the C-erbB-l/EGFR is related to carcinogenesis of bladder tumor and is important in assessing its invasiveness and the prognosis.