膀胱移行细胞癌分级诊断的研究中三种定量分析方法的评价

Evaluation of 3 quantitative analysing methods used in grading of urinary bladder carcinoma

应用ＨＩ－ＣＩ真彩色病理图像分析仪对８６例移行细胞癌的核形态，ＤＮＡ量和ＡｇＮｏＲｓ颗粒进行了定量分析。三种方法分别和综合作分级判别分析。分级结果与ＷＨＯ分级结果对比并分析他们与预后的关系。结果证明，三种定量方法在膀胱癌分级诊断中都是比较客观而有价值的方法。１级癌的判别效果最好，一致率为９０．９％～１００％。各种方法分级与ＷＨＯ一致率以形态定量法较好，为８６．０％，ＡｇＮｏＲｓ为７７．９％，ＤＮＡ为７６．７％。对预后估计的价值以ＡｇＮｏＲｓ法最好，ＤＮＡ法次之。三种方法综合分级判别可稍提高分级诊断一致率，达８８．４％。

Nucleal morphometric , DNA and AgNoRs quantification in 86 cases of urinary bladder carcinoma were analysed by computer-assisted image analysing system. The histopathological grading was compared with WHO classification. The result verified that all the 3 quantitative analyses are objective and valuable in grading of the bladder carcinoma, being the best for G1 tumors(90. 9%～100%). AgNoRs is the best for prognosis, DNA being the next. Grading with the synergic analysis of the 3 methods raised the coincidence to 88.4%.