甲状腺自身免疫病细胞因子原位免疫组织化学研究

IN SITU IMMUNOHISTOCHEMICAL STUDY OF CYTOKINES IN AUTOIMMUNE THYROID DISEASES

应用单克隆抗体免疫组织化学技术对８０例甲状腺粗针穿刺标本进行原位研究。结果发现甲状腺上皮ＤＲ抗原异常表达与活化淋巴细胞、肿瘤坏死因子、白细胞介素２和γ－干扰素呈正相关。提示细胞因子对甲状腺ＤＲ抗原的诱导、自身免疫损伤具有重要作用。

Eighty tru-cut specimens of thyroid tissues from 25 patients with autoimmune thyroiditis, 36 patients with Graves' disease,and 19 patients with thyrotoxicosis with thyroiditis were analyzed in situ with ABC immunohistochemical study and monoclonal anti- bodies specific for cytokines and HLA- DR antigen. The result showed that aberrant DR antigen expression on thyrocytes shawedpositive correlation with active lymphocytes,tumor necrosis factor, IL-2 and interferon-γ.The data suggest that cytokines may in-duce thyrocytes to express DR antigen and stimulate thyroid gland to bring about autoimmune response.