NIDDM肾病尿前列腺素的变化及其意义

FUNCTIONAL SIGNIFICANCE AND CHANGE OF RENAL PROSTAGLAND PRODUCTION IN NIDDM PATIENTS WITH DIABETIC NEPHROPATHY

作者探讨了ＮＩＤＤＭ肾病尿前列腺素（ＰＧｓ）的来源、变化的机制及意义。结果表明其主要来自肾脏；肾病早期尿ＴＸＢ２和ＰＧＥ２即显著升高，６－ｋｅｔｏ－ＰＧＦ１α无明显变化；ＴＸＢ２升高与肾功能减退及蛋白质有关，并可提示肾脏早期受损；ＰＧＥ２升高则属肾病的自身保护反应。这些变化可能与肾小球病损及肾脏血流动力学异常有关。

The source of urinary prostaglandins (PG )and the mechanism and significance of the urinary PGs changes in NIDDM patientswith diabetic nephropathy(DN) were investigated.The results indicated that the urinary PGs were primarily produced by the kid-neys. In the incipient DN, the urinary excretion of TXB2 and PGE2 were significantly augmented,but the urinary 6-keto-PGF1 excre-tion was not different from that of the control.The high production of renal TXB2was noticed in the glomerular dysfunctions ofDN,and this might reveal presence of early renal damage,However,the increased renal PGE2 synthesis could be a beneficial,self-regulating mechanism against renal damage. These biochemical alterations were associated with the pathological changes and abnor-mal hemodynamics of the glomerules.