摘要
作者探讨了NIDDM肾病尿前列腺素(PGs)的来源、变化的机制及意义。结果表明其主要来自肾脏;肾病早期尿TXB2和PGE2即显著升高,6-keto-PGF1α无明显变化;TXB2升高与肾功能减退及蛋白质有关,并可提示肾脏早期受损;PGE2升高则属肾病的自身保护反应。这些变化可能与肾小球病损及肾脏血流动力学异常有关。
The source of
urinary prostaglandins (PG )and the mechanism and significance of the urinary PGs changes in
NIDDM patientswith diabetic nephropathy(DN) were investigated.The results indicated that the
urinary PGs were primarily produced by the kid-neys. In the incipient DN, the urinary excretion
of TXB2 and PGE2 were significantly augmented,but the urinary 6-keto-PGF1 excre-tion was not
different from that of the control.The high production of renal TXB2was noticed in the glomerular
dysfunctions ofDN,and this might reveal presence of early renal damage,However,the
increased renal PGE2 synthesis could be a beneficial,self-regulating mechanism against renal
damage. These biochemical alterations were associated with the pathological changes and
abnor-mal hemodynamics of the glomerules.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1994年第2期83-85,共3页
Chinese Journal of Endocrinology and Metabolism