静脉滴注胎盘免疫球蛋白治疗慢性移植物抗宿主病的疗效观察

INTRAVENOUS PLACENTAL IMMUNOGLOBULIN FOR TREATMENT OF CHRONIC GRAFT VERSUS HOST DISEASE

静脉滴注胎盘免疫球蛋白（ＩＶＰｔＩＧ）治疗３０例慢性移植物抗宿主病（ＣＧＶＨＤ）。此３０例皆为对环胞菌素Ａ（ＣｓＡ）与皮质激素等无效的病例。ＩＶＰｔＩＧ用量为４ｇ／ｄ静点。结果表明：３０例中２６例在用药后明显好转，而且多在２周内就可见到明显疗效，，总有效率为８６，７％。患者治疗后的血清球蛋白并未升高，这说明其治疗机理可能与静注胎盘免疫球蛋白本身的药理作用有关。

ntravenous placental immunoglobulin(IV Pt IG) was used for the treatment of chronic graft ver- sus host disease(CGVHD)in 30 patients who are refractory to steroid and cyclosporinc A. 15(50%)patients showed excellant response and 11(36.66%)good response.The total response rate is 86.66%。The dosage of IV PtIG was 4 gm / day in adults by intravenous infusion. Effectiveness ofIV PtIG was discerned within 2 weeks.The plasma levels of IgG,IgA and IgM were tested before and after IV PtIG treatment.There was no significant statistical differnece between the plasma IgG,IGA,IGM levels in pre-and post-treatment period. The efficacy of IV Pt IG aganist CGVHD is therefore ascribed to its pharmacological effect.