红霉素促进非溃疡性消化不良患者胆囊运动功能的临床研究

CLINICAL STUDY OF ERYTHROMYCIN ACTION ON GALLBLADDER MOTILITY IN AP-TIENTS WITH NON一ULCER DYSPEPSIA

３２例非溃疡性消化不良伴胆囊收缩功能低下患者，给予口服红霉素０．１２５ｇ，每日３次，疗程２周。服药前后Ｂ超测定胆囊收缩功能，放免法测定空腹血浆胃动素水平。结果显示：服药前后胆囊最大排空率分别为４８．２４±８．３０ｍｌ和６９．７４±１０．７８ｍｌ，服药前后比较差异有显著性（Ｐ＜０．０１）；空腹血浆胃动素水平分别是３６１．２８±８７．９２ｎｇ／Ｌ和３９４．９７±１３４．２７ｎｇ／Ｌ二者比较差异无显著性（Ｐ＞０．０５）。研究结果提示：红霉素能增加胆囊最大排空率，并可能有外源性胃动素的作用。

hirty一two patients of non一ulcer dyspepsia(NUD) with gallbladder hypokinesia treated bv oralerythromycin administration 0.125g three times daily for two weeks.Before and after oral erythromycinadministration, gallbladder volumes were determined by ultrasound, and plasma motilin concentrationwere determined by radioimmunoassay.The results showed that before and after oral erythromycinadministration, maximal percentage emptying of gallbladder were 48.24 ± 8.30ml vs69.74 ± 10.78ml(P<0.01),plasma motilin were 361.28± 8792ng/ L vs 394.97± 134.27ng/ L(P>0.05).It is indicatedthat erythromycin could reduce fasting and postprandial residual gallbladder volumes and increasesmaximal percentage emptying of gallbladder.It suggests that erythromycin might have an agonist ac-tion on the motilin receptor as an agonist action on the motilin receptor as an exogenously administra-ted motilin.