血浆内皮素与糖尿病血管病变的关系

THE RELATIONSHIP BETWEEN THE PLASMA LEVELS OF ENDOTHELIN AND THE ANGIOPATHY IN DIABETIC PATIENTS

我们报道用放射免疫分析法测定２０例正常人及４８例非胰岛素依赖型糖尿病人血浆内皮素水平的变化，结果显示糖尿病病人血浆内皮素浓度较正常人明显增高（Ｐ＜０．００１），伴有血管并发症的病人较无并发症的病人的血浆内皮素水平亦有升高（Ｐ＜０．０２）。随着伴有的血管并发症的增多，即糖尿病病情的加重，血浆内皮素的水平也随之增高。但内皮素与血糖、糖化血红蛋白、尿白蛋白排泄率等无明显相关。因此，血浆内皮素浓度的增高可反映内皮细胞的损伤程度，提示糖尿病病人可能存在糖尿病血管并发症，但内皮素水平的增高在糖尿病血管并发症中的重要作用及病理生理意义还需进一步研究。

lasma levels of endothelin(ET),vasoconstrictor peptide released from vascular endothelial cells,have been measured by radioimmunoassay in 48 patients with NIDDM and 20 healthy subjects.The plsama ET concentrations were found to be greatly elevated in the patients with diabetes compared with the healthy subjects(P<0.001).We also find that the plasma levels of ET were higher in diabetic pa-tients with complication of diabetes mellitus than in those without complication(P<0.02).The elevated ET Ievels were related to hypertension and /or diabetic angiopathy.There were no significant correla-tions between plasma ET concentrations and blood glucose,HbAl et al.In diabetic patients elevated ET levels may play a pathophysiological role in the development of diabetic complication.