国产环丙沙星与氧氟沙星的临床疗效

CLINICAL EFFICACY OF CIPROFLOXACIN AND OFLOXACIN

１９９２年，在北京及广州的５所临床医院有关科室对国产环丙沙星（Ｃｉｐｒｏｆｌｏｘａｃｉｎ，ＣＰＬＸ）与氧氟沙星（Ｏｆｌｏｘａｃｉｎ，ＯＦＬＸ）的临床疗效、抗菌活性与不良反应作了前瞻性对比观察。两组各１００例。经一疗程治疗，总治愈率为７９％，有效率９４％两组临床疗效无差异，Ｐ＞０．０５，病原阳性率均为９５％，一疗程后转阴率ＯＦＬＸ组为９５．８％，ＣＰＬＸ组为８７．４％Ｐ＜０．０５，共检出病原菌ＣＰＬＸ组９９株，ＯＦＬＸ组９６株，清除率分别为８７．９％９５．８％Ｐ＜０．０５。两组不良反应发生率ＯＦＬＸ组１２％，ＣＰＬＸ组２１％且后者有１倒退出治疗。总的看来，两药对消化、泌尿系细菌感染及淋病疗效及安全性非常可靠，对呼吸道感染疗效亦非常显著，ＯＦＬＸ在细菌清除及不良反应发生率方面优于ＣＰＬＸ。

he clinical efficacy,antibacterial activity and adverse effects of ciprofloxacin(CPLX) and ofloxacin(OFLX)produced in our country were compared in five clinical hospital in Beijing and Guangzhou in 1992.Two groups,each consisting of 100 cases, were treated with CPLX and OFLX respectively The total cure rate was 79% and effective rate 94% after one course of treatment,There was no difference between the two groups(P>0.05). The positive rate of presence of pathogens was 95% in both groups, but the rate of transfonnation from positive to negative after one course of treat-ment was 95.8% (OFLX) and 87.4%(CPLX)respectively. The difference between the two groups was significant(P< 0.05)99 and 96 strains of bacteria were detected in the CPLX and OFLX group respectively;the elimination rate was 87.9% and 95.8%(P<0.05).Incidence ofadverse effects was 12% (OFLX)and 21%(CPLX)respectively.In a word ,both drugs are effective in treating bacterial infections.of digetive system, urinary system and respiratory tract.They are safe and reliable. OFLX is better than CPLX in bacteria elimination and incidence of adverse effects.