变应性肉芽肿性血管炎

CHURG-STRAUSS VASCULITIS

报道８例变应性肉芽肿性血管炎（Ｃｈｕｒｇ－Ｓｔｒａｕｓｓｖａｓｃｕｌｉｔｉｓ），该病临床主要以过敏性鼻炎（６９％）、副鼻窦炎（８８％）、哮喘（９８％～１００％）、多发性单神经炎（６６％～９８％）、肺内浸润、周围血嗜酸细胞显著增多为特征。病理学检查可见组织嗜酸细胞浸润，肉芽肿病变，坏死性血管炎。这些病理变化可局限或广泛分布，以上病变不一定同时出现，可孤立或混合存在。单次组织活检可能看不到病变全貌。按照１９９０年美国风湿病协会血管炎分会提出６项关于本病的诊断标准。本组８例中６例符合该诊断标准，２例由病理检查证实。对本病的诊断应侧重临床表现。本病对皮质激素反应良好，治疗效果较明显。

he author reported a clinical study of 8 cases of Churg-Strauss vasculitis which is a rare disease of unknown cause.The clinical features include allergic rhinitis (69%),sinusitis (88%),asthma (98%～100%),mononeuropathy (66%～98%),pulmonary infiltration and peripheral blood eosinophilia. The histopathologic manifestations are characterized by eosinophilic infiltration,granulomatous lesion and necrotising vasculitis.The lesions mentioned above may not appear simultaneously, but they may exist in different combinations.Therefore,not all the manifestations may be seen in a single biopsy specimen. According to the diagnostic criteria recommended by American College of Rheumutology Subeommittee on Classification of Vasculitis in 1990, 6 cases of this series can be diagnosed. The re-maining 2 cases were confirmed by pathologic examination, This kind of vasculitis responds to steroid treatment with satisfactory results.