自身免疫性甲状腺疾病尿微蛋白及血β＿2微球蛋白的变化

THE CHANES OF URINE PROTEIN AND SERUM β_2-MICROGLOBURIN INAUTOIMMUNE THYROID DISEASE

用放射免疫方法对未治疗的３９例自身免疫性甲状腺疾病（２８例Ｇｒａｖｅｓ病，１１例桥本病）的血β＿２微球蛋白、尿白蛋白、ｌｇＧ、微微球蛋白进行测定。结果表明：Ｇｒａｖｅｓ病人微蛋白尿发生率为２８．６％，血β＿２微球蛋白与对照组相比呈有意义的增高。桥本病尿微蛋白发生率为４５．５％。二组病人肾小球及肾小管均有损伤。对其发生机理进行了探讨。

ecause of the different observed results about the microproteinuria in autoimmune thyroiddisease,serum B2-MG, urine B2-MG,albulin and immunoglobin by RIA in 39 untreated autoimmunethvroid disease(AITD)(2 8 with Graves disease and 11 with Hashimoto disease)had been observed.Micro-proteinuria was found in 28.6% of patients with Graves disease and in 45.5% with Hashimotodisease; Serum B2-GM concentrations were significantly increased in Graves disease compared withthat of controls. Our results suggest that the lesions present in both glomerulus and tubulus in AITD.The mechanism of them had been discussed in this paper.