摘要
对196例可疑的干燥综合征(SS),患者作了唇腺活检(LSG-B)和Schirmer试验、角膜荧光染色和SS-A/sS-B抗体等免疫学检查。196例中117例LSG-B≥2个灶/4mm ̄2,其中92例同时有干燥性角膜结膜炎(KCS),符合Talal的SS诊断标准。余25例LSG-B阳性而不伴有KCS者,16例符合继发性SS(2°SS),9例有SS的临床特征表现和SS一A/SS-B阳性而不能排除SS。此外LSG-B(-)而有KCS阳性者11例均符合原发性SS(1°SS)或2°SS。本组128例SS中LSG-B的阳性率为91%。我们还发现2°SS在LSG-B中的灶性涎腺炎严重程度明显轻于1°SS,而在1°SS中灶性涎腺炎的严重程度与系统累及呈正相关。
abial salivary gland biopsy(LSG-B)along with Schirmer test and kerato-conjunctival staining with fluorescein dye was performed in 196 patients with suspected Sjogren's syndrome(SS). of the 196patients, 117 were found to have 2 or more lymphocytic focus scores(LFS/4mm ̄2) on their LSG-Bspecimens.92 of them having keratoconjunctivitis sicca(KCS) as well met the diagnostic criteria of SS.Among the cases (25) without KCS, 16 with another CTD were diagnosed as secondary SS. 9 cases wereclassified as probable primary SS in this study because they had clinical manifestations of SS. Of the 11cases with KCS only,6 with another CTD were diagnosed as secondary SS; 5 befitted primary SS forabnormal findings on sialography. We also found that lymphocytic infiltration in LSG-Bwas muchmore severe in primary SS than in secondary SS; this could be attributed to the use of immunotherapyfor the accompaning CTD in secondary SS. There was good association in our study between the severi-ty of lymphocytic infiltration and systemic involvement.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1994年第9期597-600,共4页
Chinese Journal of Internal Medicine
关键词
唇腺
活检
干燥综合征
Sjogren s syndrome Labal salivary gland biopsy