氢化可的松和氟美松对人红细胞膜胰岛素受体的影响

THE EFFCT OF HYDROCORTISONE OR DEXAMETHASONE ON HUMAN ERYTHROCYTE MEMBRANE INSULIN RECEPTOR

实验结果发现，口服氢化可的松（１．２５ｍｇ／ｋｇ）和氟美松（３７．５μｇ／ｋｇ）后红细胞膜胰岛素受体的最大特异性结合率（Ｂ／Ｔ）显著下降，血浆胰岛素浓度显著升高，而血糖无明显变化。Ｓｃａｔｃｈａｒｄ图显示结合率的改变主要不是受体亲和力和数目变化所致。体外实验结果表明两者对红细胞膜胰岛素受体的结合无显著影响。提示两者对胰岛素受体的影响是多层次的，包括胰岛素的分泌和受体与胰岛素的结合。

t is shown that the maximum specific binding rate (B/T)of erythrocyte membrane receptor to in-sulin was significantly decreased,the concentration of plasma insulin was significantly increased and the level of plasma glucose was not obviously changed after taking hydrocortisone(1.25mg/kg) or dexamethasone(37.5μg/kg)orally.Scatchard analysis showed that decreased B/T was not mainly due to the change of the affinity or number of foci of insulin receptors,as no significant influence on insulin binding was found in vitro; The data suggested that the effect of both drugs on insulin receptor was multifactorial, including the secretion of insulin as well as the combination of insulin to its receptors.