肝硬化患者胆囊胆汁脂类、胆红素及金属元素的改变

CEANGES OF LIPIDS,BILIRUBIN AND METAL ELEMENTS IN THE GALLBLADDER BILE IN PA-TIENTS WITH CIRRHOSIS OF LIVER

观察２４例肝硬化患者胆囊胆汁脂类、胆红素及金属元素改变。发现肝硬化患者胆囊胆汁中总胆汁酸、磷脂水平下降；未结合胆红素、铁含量增高；胆汁粘度下降，具有明显成色素性结石趋势。提示胆汁成分改变是肝硬化患者易于并发色素性结石的基础。

he aim of this study is to observe the changes of bile elements in patients with cirrhosis of liver and to analyse the relationship with stone formation,The gallbladder bile in 24 patients with cirrhosis of liver was obtained with aspiration during operation, The levels of lipids,bilirubin and various metal elements such as potassium, sodium,calcium, magnesium,copper,iron, and zinc in the bile were determined. Elevated unconjugated bilirubin(UCB)level (P<0. 02) and decreased levels of total bile acid(TBA)(P<0. 001), total cholesterol (TC)(P<0. 001),phospholipids (PL)(P<0. 05 ) and bile viscosity(P<0. 001 ) were found.The levels of potassium,magnesium, copper and zinc in the bile decreased(all P values less than 0. 001),while the level of iron increased (P<0. 02) significantly in cirrhotic patients。The results showed that there is an obvious tendency for gallbladder bile in cirrhotic patients to form pigment stones.