多形性日光疹的临床类型和光试验研究

Clinical Subtypes and Phototesting Studies on Patients with Polymorphous Light Eruption

对３１１例多形性日光疹（ＰＭＬＥ）患者的研究可将其分为丘疱疹型、小丘疹型、大丘疹形、红斑水肿型和混合型等五个临床亚型。分别测定其对ＵＶＡ和ＵＶＢ的最小红斑量（ＭＥＤ），双变量相关分析示在ＰＭＬＥ及其五个亚型中缺乏正常对照组中存在的正性相关关系。小丘疹型中对ＵＶＡ和ＵＶＢ的ＭＥＤ值以及在红斑水肿型中对ＵＶＢ的ＭＥＤ值均见显著减低。表明ＰＭＬＥ各亚型的临床特征和作用光谱不尽相同，可能还包含着几组发病机制不同的光敏性皮肤病。

A study of 311 patients with polymorphous light eruption (PMLE ) indicated that five subtypes were recorded as papulovesicles, small papules, large papules, edemadous erythema, and mixed rashes. Minimal erythema dose (MED) for both UVA and UVB were tested. Bivariate correlation analysis of all PMLE patients did not show a positive correlation between MED--UVA and MED-UVB as in the healthy controls. The MED-UVA and MED-UVB in patients with small papule subtype, and MED-UVB in edematous erythema subtype were significantly reduced which indicate that the clinical features and the action spectra are not the same in all PMLE subtypes. These results show that the term 'PMLE' may still encompass several photosensitivity conditions with different pathogenetic mechanisms.