血浆纤维结合蛋白在肾移植中的监测价值

Evaluation on Plasma Fibronectin Monitoring in Renal Transplant Recipients

对４１例透析治疗准备肾移植的患者作移植前、后的血浆纤维结合蛋白（ＰＦｎ）浓度的动态监测发现，移植术前ＰＦｎ低于正常；移植术后肾功能稳定组ＰＦ。逐渐恢复正常；急性排斥反应组ＰＦｎ浓度下降，随排斥逆转，肾功能恢复，ＰＦｎ又上升到正常，而不可逆急性排斥时，ＰＦｎ始终波动在极低水平；术后并发感染时，感染初期ＰＦ，一过性增高。结果表明，动态测定ＰＦｎ水平，对了解移植肾功能状态，预测排斥及并发感染的发生和演变，估计疗效和预后有一定价值。

Plasma fibronectin (PFn) concentrations in 41 patients with chornic renal failure (CRF) were detected before and after renal transplantation. The results showed that dialysing patients had lower PFn levels than these in normal control. The PFn in recipients with normal graft function returned to normal levels by the fourth postoperative day, and in recipients with rejection episode showed a significant decrease which could return to normal after the function of the graft improved, while the PFn levels were persistently very low in patients with irreversable acute rejection. During the initial phase of infction, a transient incresse in the mean PFn level was observed. The results suggested that PFn monitoring might provide valuable information about renal function status and the prognosis of rejection and infection.