2型糖尿病患者血清脂联素水平的变化

Adiponectin levels of patients with type 2 diabetes mellitus

目的探讨人血清脂联素水平与2型糖尿病的关系。方法2型糖尿病患者47例和正常对照46例,两组年龄、性别匹配,采用酶联免疫分析法检测其空腹血清脂联素、胰岛素水平,同时测血糖、血压、血脂、身高、体重、腰围、臀围,计算体重指数(BMI)、腰臀比值和胰岛素敏感指数(ISI)、胰岛β细胞功能。结果2型糖尿病组的脂联素水平减低,脂联素水平在糖尿病超重组低于糖尿病正常体重组和对照组;相关分析显示脂联素水平与BMI呈负相关,与ISI正相关。结论脂联素做为脂肪组织分泌的一种细胞因子,在2型糖尿病患者中其血清水平降低,且与肥胖相关,因此提示脂联素水平增加对于肥胖及糖代谢紊乱的治疗可能是有益的。

Objective To measure the serum adiponectin levels of patients with type 2 diabetes mellitus,so as to examine whether there exist a relationships between resistin, obesity and diabetes. Methods ELISA was used to examine resistin concertration in 48 patients with type 2 diab etes and the results were compared with 47 healthy control subjects.Meanwhile we examined plasma level s of insulin,glucose,TG and TCH,and measured height,body mass index and waist hip ratio, insulin sensitivity index and HOMA-β. Results Them ean concentration of adiponectin in serum from type 2 diabetic patients was signific antly lower than that in nomal subjects. And the adiponectin levels in obese dia betes was lower than that in the nonobese diabetes and contrals. The serum adi ponectin concentration was siginificantly correlated with BMI in both normal subjects and patients with type 2 diabetes. A correlation was observed between serum resistin levels and ISI, WHR, HOMA-β in nomal subjects. Conclusion The mean concentration adiponectin,a adipocytokine secreted by adipocyte s was significantly lower in serum from type 2 diabetic patients than in nomals ubjects.We demonstrated that adiponectin was correlated with obesity.So we think any treatment which increase adiponectin seems to be beneficial to obesity and glucose metabolism.