心脏起搏患者血浆利钠肽水平与生理活动量的关系

Daily physical activity and plasma natriuretic peptides level in patients with implanting pacemaker

目的了解心脏起搏术后患者生理活动量与血浆心房利钠肽(ANP)、脑钠肽(BNP)水平的相关性及不同等级生理活动量之间血浆ANP、BNP水平的差异。方法用放射免疫法测定62例起搏患者的血浆ANP、BNP浓度,其中DDD17例,VVI39例,VVIR2例,VDD4例,根据特定活动量等级问卷调查来判断起搏患者的生理活动量,选择Ⅰ级、Ⅱ级及Ⅲ级入组进行研究。结果起搏患者生理活动量与血浆ANP水平有良好的相关性(r=0.39,P<0.01),生理活动量与血浆BNP水平相关性更显著(r=0.63,P<0.01)。血浆ANP水平在生理活动量Ⅲ级>Ⅱ级(P<0.05),>Ⅰ级(P<0.01),血浆BNP水平在生理活动量Ⅲ级>Ⅱ级(P<0.001),>Ⅰ级(P<0.001)。结论起搏患者的生理活动量与血浆ANP、BNP水平显著相关,可以用血浆ANP、BNP水平大致判断起搏患者的生理活动量,间接判断患者的心功能。且以血浆BNP水平衡量患者的生理活动量较血浆ANP水平更敏感。

Objectives To determine whether daily physical activity scales after pacemaker implantation is correlated with plasma ANP and /or BNP.Methods The plasma ANP and BNP levels were measured by radioimmunoassay in 62 patients with pacemaker implantation DDD17, VVI39, VVIR2, VDD4. Daily physical activity scales were evaluated by a specific activity scale questionnaire. Results There were significant correlation bet ween daily physical activity scales and plasma BNP (r=0.63, P<0.001) and ANP (r=0.39, P<0.01) levels, plasma ANP level in patients with daily ph ysical activity classⅢ was significantly higher than that in classⅡ(P<0.0 5) and classⅠ(P<0.01); while plasma BNP level in classⅢ significantly, higher than in classⅡ(P<0.001) and classⅠ(P<0.0001). Conclusions Plasma ANP or BNP levels can determine daily physical activity; the higher the level of daily physical activity scale, the lower the plasma ANP or BNP levels. BNP level is more sensitive than ANP level.