中枢神经细胞瘤研究进展

Research advance of central neurocytoma

中枢神经细胞瘤是一种少见的神经元来源的脑室内肿瘤,大多呈良性,预后良好。其组织学病理特征为肿瘤细胞来源相同、体积小、大小一致、排列紧密。磁共振波谱特征包括胆碱增高、肌酸和N-乙酰天门冬酸盐减少。最佳的治疗方法是手术治疗,术后辅助放疗、化疗可以提高局部控制率或患者的生存率以及降低复发率。MIB-1标记指数在提示预后上价值较大。本文就近年来其影像、病理和临床等方面的研究进展做一综述。

Central neurocytomas are rare intraventricular neuronal neoplasms of the central nervous system. Typically,they are benign tumors and patients with central neurocytomas have a favorable prognosis. The central neurocytoma is composed of homogenous,small uniform cells. General patterns of the proton magnetic resonance of central neurocytoma include elevated choline,decreased creatine and NAA. The most effective therapeutic modality is surgery,and adjuvant radiation therapy and chemotherapy can be added to improve local control or increase survial,and decrease recurrent rate. The proliferation markers MIB-1 is useful in predicting relapse. This paper summarizes the recent advances in imaging,neuropathology and clinical theraphies.