白细胞介素-6与牙周组织的改建

Relationship between interleukin-6 and periodontium remodeling

白细胞介素-6是一种来源广泛的多功能细胞因子,与牙周组织改建有密切的关系。咬合力废用和代偿,均诱导牙周膜细胞和牙槽骨成骨细胞表达IL-6蛋白及mRNA明显增加。IL-6通过作用于破骨细胞前体来促进骨吸收,也能够抑制牙周膜细胞的生长,从而影响组织的修复和代谢功能;它还能促进成骨细胞的分化,促进骨的形成,是牙周组织改建的重要细胞因子。

Interleukin-6(IL-6) is one kind of multifunctional cytokine,which can be produced by many kinds of cells,and has intimate relationship with periodontium remodeling.Decreased or increased bite force may induce apparent expression of IL-6 in PDLC and osteoblasts.IL-6 stimulates osteoclast formation and enhances bone resorption,most likely by increasing the pool of early osteoclast precursors that in turn can differentiate to mature osteoclasts.IL-6 inhibites the growth of periodontal ligament cells in a time and dose dependent manner.IL-6 can also promote osteoblast differentiation and stimulate bone formation in vitro and in vivo .It is indeed responsible for the periodontium remodeling.