蒙古族腔隙性脑梗死患者的ACE基因多态性研究

The ploymorphisms of ACE gene in mongol patients with lacunar infarction

目的探讨血管紧张素转换酶(ACE)基因与蒙古族腔隙性脑梗死(LI)的关系和ACE基因I/D多态性的遗传规律。方法采用聚合酶链反应(PCR)扩增方法检测33例LI患者和30例健康人的ACE基因型,并对两者ACE基因I/D多态性进行对比分析。结果患者ACE基因DD基因型及D等位基因频率为(0.3,0.47)明显高于对照组(0.1,0.25),二者相比有显著性差异(P<0.05)。结论ACE基因插入(I)/缺失(D)多态性与蒙古族LI患者有关,ACE基因DD基因型或D等位基因可能是蒙古族LI患者的遗传学基础之一。

Objective To investigate the association between lacunar infarction (LI) and the angiotension converting enzyme (ACE) gene from the polymorphisms of insertion (I) and decetion (D) in mongol nation patients with LI verified by MRI and CT,and investigate heredity regularity in the polymorphisms of ACE gene I/D.Methods Polymerase chain reaction (PCR) was used to test the ACE genetypes of 33 patients with LI and 30 healthy adults were tested as controls.The results were analized by statistical technique;At same time,polymorphisms of ACE gene I/D were compared among the healthy adults in different national areas.Results The frequencies of DD homogenesis ( 0.3 ) and allele ( 0.47 ) in patients with LI were significently higher than those in controls( P < 0.05 ) and there was significent difference between these two groups:Polymorphisms of ACE gene I/D among the healthy adults in different areas had statistical difference.Conclusions There is an association between the LI in mongol nation people and the polymorphisms of insertion (I) and decetion (D) in ACE gene.DD homogenesis or Dallele of ACE may be one of the heredity reason for LI in mongol nation people;ACE genetypes and allele frequency have difference in both nations and races.