坏死性肌病9例临床与病理分析

Necrotizing myopathy (9 cases report)

目的探讨坏死性肌病的临床和病理特点及其对药物的治疗反应。方法采用回顾性研究方法。结果患者的临床表现同多发性肌炎(PM),肌肉活检显示肌纤维变性、坏死,部分有吞噬现象,但无炎性细胞浸润;患者对激素联合免疫抑制剂治疗有效;年龄较大、病程较长、用药较晚者治疗效果差。结论坏死性肌病可能为PM的特殊类型,患者对激素合并使用免疫抑制剂有效。

Objective To explore clinical and pathological characteristics of necrotizing myopathy,and its response to treatment.Methods Retrospective research method.Results The presentation of necrotizing myopathy was similar to polymyositis.Muscle biopsy showed that there was no perimysial,perivascular or endomysial mononuclear cell infiltrates,although phagocytosis of necrotic fibers was evident.Patients with necrotising myopathy were response to coticosteroid combined with immunosuppressive treatment. The older,long duration and delayed treatments were factors that resulted in poor outcome.Conclusions Necrotic myopathy may be a special type of polymyositis.The patients were response to steroids in combination with immunosuppressive treatment.