退黄煎剂直肠滴注治疗新生儿高胆红素血症的临床研究

Clinical Study on Effect of Tuihuan Decoction Rectoclysis in Hyperbilirubinemia of Newborn

目的探讨直肠滴注中药退黄煎剂治疗新生儿高胆红素血症的临床疗效和方法的可行性。方法175例新生儿高胆红素血症患儿随机分为治疗组和对照组,对照组采用西药加双面蓝光治疗;治疗组在上述基础上加用中药退黄煎剂直肠滴注;治疗过程中每天用微量血胆红素检测仪检测血胆红素浓度,观察黄疸消退时间、血胆红素下降速度、肝功能变化及光疗后胆红素反跳情况。结果治疗组治疗7天黄疸治愈率高于对照组,差异有显著性(P<0.05);平均每日胆红素下降速度治疗组优于对照组,差异有显著性(P<0.01);肝功能(AST、ALT、γ-GT)改善治疗组优于对照组,差异有显著性(P<0.01);光疗后胆红素反跳率治疗组低于对照组,差异有显著性(P<0.05)。结论中药退黄煎剂直肠滴注治疗新生儿高胆红素血症疗效显著,并可预防光疗后胆红素反跳现象发生,是治疗新生儿高胆红素血症的理想方法。

ObjectiveTo study the therapeutic effect and feasibility of rectoclysis with Tuihuang decoction (RTD) in treating hyperbilirubinemia of newborns. MethodsOne hundred and seventy-five newborns with hyperbilirubinemia were randomly divided into the treated group and the control group. They were treated with western medicine plus double faced blue treatment while the treated group were given RTD additionally. Blood bilirubin was detected by micro-bilirubin detector daily during the treatment course. The time of jaundice regression, the speed of blood bilirubin reducing, liver function, and condition of rebounding were observed. ResultsThe 7-day curative rate of jaundice in the treated group was superior to that in the control group, showing significant difference (P<0.05). The average speed of blood bilirubin reducing daily in the treated group was quicker than that in the control group (P<0.01). The improvement of liver function, such as AST, ALT and γ-GT in the treated group was superior to that in the control group (P<0.01). Rebound rate of blood bilirubin in the control group was significantly higher than that in the treated group (P<0.05). ConclusionRTD is an ideal therapy for treatment of hyperbilirubinemia of newborn, it shows obvious clinical efficacy and can effectively prevent the rebound of blood bilirubin.