摘要
毛细血管内增殖性肾炎是临床上常见的免疫复合物介导的肾小球肾炎,国内尚未见稳定、简便制作该肾炎模型的报道。本研究对传统的慢性血清病肾炎作了较大改进,成功地重复制备了大鼠典型的毛细血管内增殖性肾炎模型,简介如下。材料与方法一、实验动物与分组SD雄性大鼠20只,体重150～200 g,随机分为实验组(15只)和对照组(5只)。二。
This study succeeded in establishing the experimental model of diffuse endocapillary proliferative glomerulonephritis by modified chronic serum sickness in rats. After 7 weeks immunizaiton, the pathological changes showed both endothelial cell and mesangial cell proli-ferations arid typical hump under epitheliumby EM. The experimental rats presented he-avy protcinuria. The experimental model of endocapillary proliferative glomeruionephritis was first reported in China. This model is highly reproducible and practical.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1994年第2期108-108,共1页
Chinese Journal of Nephrology
