肾病综合征钠潴留状态下血管紧张素和醛固酮的变化

IS THE ANGIOTENSION-ALDOSTERONE IN-VOLVED THE SODIUM RETENTION IN THE NEPHROTIC SYNDROME

本文对２８例肾病综合征在钠潴留状态下，即尿钠排出小于钠的摄入三天以上，体重每日至少增加０．５ｋｇ，用放射免疫法测定其血管紧张素Ⅱ（ＡＴＩ）和醛固酮（Ａｌｄ）。结果显示钠潴留和ＡＴⅡ、Ａｌｄ缺乏相关性。ＡＴⅡ和血白蛋白呈负相关。而ＡＴⅡ、Ａｌｄ和红细胞压积、肾小球滤过率无关。

he level of angiotension and aldosterone weredetermined by RIA in 28 patients with nephrotic syn-drome. The patients were all studied during a phase ofsodium retention as judged by their urinary sodium ex-cretin being less than their intake for at least 3daysand by a weight gain of greater than 0. 5kg each day.The presence of sodium retention have no obvious re-lation with the level of angiotension and aldosterone.There was significant negative correlation betweenlevel of angiotension and plasma albumin. Althoughthe hematocrit and GFR have no relation with the an-giotension and aldosterone.