IgA肾病肾间质中淋巴细胞亚群浸润的意义

THE ANAYLSIS OF INTERSTITIA INFILTRATION OF LYMPHOCYTE SUBSETS IN IgA—N

IgA肾病(IgA-N)为一组具有不同临床表现和进程的综合征。为了解IgA-N肾间质淋巴细胞亚群浸润的意义,我们分析了71例IgA-N肾间质淋巴细胞亚群与临床病理的联系。材料与方法 71例肾活检证实的原发性IgA-N,男性40例,女性31例,平均年龄29.73岁。临床上表现为反复发作性肉眼血尿者(R-GH)有9例;孤立性肉眼血尿者(I-GH)7例;无症状尿检异常(Uab)36例;肾病综合征(NS)8例,非肾病性大量蛋白尿(MP)3例;高血压(HT)8例。7例已发生肾功能不全。肾小球及间质小管病变程度:Ⅰ级10例;Ⅱ组29例;Ⅲ组9例,Ⅳ组9例。系膜区单纯IgA沉积者有14例;IgA+IgG复合沉积25例;IgA+IgM复合沉积3例;IgA+IgG+IgM复合沉积29例。

Lymphocyte subsets infiltrated in interstitium of IgA—N were analysed The numbers of T, B lymphoeytes infiltrated in interstium were varied with histologicl lesions, immuuopathologie types and clinical manifestations. The more severe of histologic lesions, the higher the numbers of T, B lymphocyte subsets, the lower of the CD CD ratios. It is suggested that lymphocyte subsets may be regards as one of marks to classified IgA—N, and also it may be predicated the severity of histological lesions.