超临界流体强制分散溶液对麻黄素的超细化

MICRONIZATION OF EPHEDRINE THROUGH SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUID

以乙醇为溶剂,超临界CO2为抗溶剂,采用超临界流体强制分散溶液技术成功地对麻黄素进行了超细化.采用SEM照片分析微粒的形貌,利用粒度分析仪测定微粒的平均粒径.在实验范围内得到了断面直径约0.58～1.21μm的非团聚短棒状或长棒状麻黄素微粒.CO2流量较高时得到断面直径细小的短棒状微粒,低的溶液浓度趋于得到细小的溶质微粒,操作压力及操作温度对微粒尺寸及形貌无显著影响.

Ephedrine has been successfully micronized through solution enhanced dispersion by supercritical fluid (SEDS),with ethanol used as the solvent and carbon dioxide-the antisolvent.This process is known as the particle formation method.Morphology of microparticles is examined by use of SEM.Particle-size (PS) analyses are performed by use of N4-Plus Coulter.Under experimental conditions,the precipitates present long-rod-like and short-rod-like uncoagulated microparticles with PS being 0.58~1.21 μm in width.Short-rod-like microparticles with small particle sizes in width can be obtained at a high CO_2 flow rate.When solution concentration is low,the PS of microparticles appears to be small.No evident dependence of PS on temperature and pressure is observed.