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胰岛素曲线的数学模型研究——(3)抛物线法

Research on mathematics model of insulin curve——(3) Parabola model
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摘要 胰岛素曲线的数学建模是胰岛素曲线应用于临床的关键环节,它对于糖尿病的治疗、胰岛素泵的研制等都具有及其重要的意义,同时对于揭示人体胰岛素分泌的内在规律也具有非常重要的意义。然而长期以来,人们对胰岛素曲线的认识只是停留在经验曲线图形上,没有对其进行数学上的分析和量化的计算,因而人们对胰岛素曲线的应用,还停留在起步阶段。胰岛素曲线的基础量部分是直线(各个时段基础量有差异,严格来说是分段直线);胰岛素曲线的大剂量(有的文献称为餐前量)部分是一段复杂的曲线。笔者为研制胰岛素泵,对胰岛素曲线进行了深入研究,提出了大剂量胰岛素曲线的三种数学模型(分别称为正态分布法、梯形法和抛物线法),并求出其对应的数学函数表达式,并对这些模型函数进行了详细的分析和计算,取得其主要参数计算公式,从而使胰岛素曲线进入了数字量化的研究阶段,为胰岛素曲线在糖尿病的临床治疗和医学研究(包括胰岛素泵的研制)中的应用奠定了坚实的基础。本文介绍其中的抛物线法。 Mathematics modeling of insulin curve is sticking point about the application insulin curve to clinic insulin curve. It is important to treatment on diabetes and research on an insulin pumb,and it is also important to opening out the rule of insulin excreting. But,people know longtime insulin curve which is only an experiential curve,and haven't analyzed in mathematic method. Because researching on an insulin pumb, Penman has studied home the curve,and brought forward 3 sorts mathematic models(normal school model,trapezoid model,parabola model),and brought out their function expressions. It has promoted that research on insulin curve reach digital phase. This article introduces the parabola model.
出处 《中国医学装备》 2004年第4期50-51,共2页 China Medical Equipment
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  • 1Skyler JS,Scigler DE,Rcaves ML.Optimizing pumped insulin delivery[].Diabetes Care.1982
  • 2Opaolisso G,Scheen AJ,Giugliano D,et al.Pulsatile insuline delivery has greaten metabolic effects than continuous hormone administration in man: improtance of pulse frequency[].Journal of Clinical Endocrinology and Metabolism.1991
  • 3Paskin P.Treatment of type I diabetes with portable insulin infusion devices[].Diabetes Care.1982
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