流行性出血热患者胃粘膜内病毒抗原定位的研究

Study on Epidemic Hemorrhagic Fever Virus Antigen in Gastric Mucosa of Patients

１９８６～１９８９年在对１２０例流行性出血热（ＥＨＦ）患者进行胃镜诊治中发现，胃粘膜具有明显的形态学和病理学变化。为研究其发病机制，应用免疫组化酶染法对２０例ＥＨＦ患者的胃粘膜进行ＥＨＦ病毒抗原定位检测，１７／２０例获得阳性结果，初步阐明了上消化道出血／胃粘膜损害与ＥＨＦ病毒抗原的亲嗜及侵袭有关。

From 1986 to 1989, gastroscopy was performed on 120 patients with epidemic hemorrhagic fever (EHF). Changes in morphology and pathology in gastric mucosa were found. In order to explore the pathogenesis, virus antigen of EHF in 20 sampls of gastric mucosa were detected by immunohistochemical staining. Results were positive in 17 of 20 samples, suggesting that the lesion of gastric mucosa was directly related to the virus antigen of EHF.