急性、亚急性重型肝炎细胞坏死图像计量分析与预后的关系研究

Study on the Relationship between the Area of Necrosis of Hepatocyte and Prognosis by Using Morphometrical Assessment in Patients with Fulminant Acute and Subacute Viral Hepatitis

以形态计量方法，用图像测析仪、电子计算机测量肝细胞面积，结果发现，急性重型肝炎存活２１例与死亡１８例的肝细胞坏死的平均面积分别为２７．９％±１７．４％与７７．１％±２７．９％（Ｐ＜０．０５）。亚急性重型肝炎存活１４例与死亡２５例的坏死面积平均分别为３０．５％±２７．０％与４５．２％±２４．０％（Ｐ＜０．０５）。表明急性亚急性肝炎存活者比死亡者的肝细胞面积较轻，提示肝细胞由变性至坏死是不同时期不同阶段的表现，若及早治疗，顿挫坏死的发展，可逆转病情。将细胞计量学技术用于重型肝炎的病理分析，有利于评价疗效与估测预后。

the areas of necrosis of hepatocytes were assayed by using the image analysis system and computer in patients with fulminant viral hepatitis.In patients with fulminant acute viral hepatitis the areas of necrosis of hepatocytes were 27.9% ±17.4 % at survival and were 77.1% ± 27.9% at death (P<0.05);in patients with fulminant subacute viral hepatitis the areas of necrosis of hepatocytes were 30. 5% ± 27. 0% at survival and were 45.2%±24.0% at death (P<0.05).The results indicated that the areas of necrosis of hepatocytes at survival was not serious than at death in patients with fulminant viral hepatitis. The results suggested that the course from degeneration to necrosis of hepatocytes reflected different disease periods and stages. If the patient could betreated at early period,the necrosis of hepatocytes would be impeded and the patient's condition might be favourable.To assay the pathology of fulminant viral hepatitis by using the cell morphometricanalysis might evaluate the patient's condition and judge the prognosis for fulminant viral hepatitis.