烧伤早期血浆精氨酸加压素和β-内啡肽的动态分析及临床意义

Changes of arginine vasopressin and p-en-dorphin in plassma of burned patients

本文测定了三组24例不同程度烧伤病人血浆精氨酸加压素免疫活性物质(ir-AVP)和β-内啡肽样免疫活性物质(ir-β-EP)含量的变化及部分生化指标,发现AVP和β-EP含量均显著升高并与烧伤面积有关,血生化指标也有相应变化。

The importance of arginine vasopressin (AVP) and (3-endorphin (B-Ep) in shock has been increasingly recognized. Radioim-munoassay on immunoreactive arginine vaso-presin (ir-AVP) and immunoreactive -endor-phin (ir-B-Ep) in plsma samples from 24 burned patients of variable severity showed that ir-AVP and ir-B-Ep increased significantly within 8 hours postburn. The increasing rate of ir-AVP and ir-B-Ep dependeds on the TBSA of the patients. AVP increased to a peak at 16 hour postburn, most noticeable in severely burned patients. B-Ep increased to a peak within 8 hours postburn. Both AVP and B-Ep restored to normal approximately at 48 hour. During the polyurla stage, contents of ir-AVP, Na, and total protein in plasma were less than normal value and glucose was elevated compared with those of the normal uria stage. The change of albumin, urea nitrogen and osmolarity was not marked.